It's also important to get advice on possible interactions with your current use of medicine, vitamins or minerals. Bitter orange is a currently available herbal stimulant used in some weight-loss supplements and is often called an ephedra substitute. The active ingredient in bitter orange has chemical properties and actions that are similar to ephedra and may be associated with similar adverse effects. Because of limited research and the use of bitter orange in multi-ingredient supplements, the safety of the product isn't well-understood.
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